Scientific Program

Day 1 :

  • Hypertension | Antihypertensive drugs | Non-pharmacologic Intervention | Hypertension in patients with Comorbidities
Location: Toronto, Canada
Speaker
Biography:

Dr. Kapila has done Ph.D. in human genetics. After completing Ph.D., she was teaching in Khalsa College Amritsar for the past four years. She has published more than six papers in scientific journals. She has been recently appointed as an Assistant Professor in DAV College Jalandhar, Punjab India. 

Abstract:

Essential hypertension is a heterogeneous disorder with both genetic and environmental causal factors responsible for its etiology including dyslipidemia. Dyslipidemia trigger the activation of sympathetic nervous and renin-angiotensin-aldosterone systems and also imbalance the oxidant-antioxidant status causing impaired vasodilation leading to elevated blood pressure (Muñoz-Durango et al, 2016). Therefore, in the present study, lipid profiling was carried out. The atherogenic index (LDL-C/HDL-C), coronary risk index (TG/HDL-C) and ratio of total cholesterol to high density lipoprotein-cholesterol (TC/HDL-C) were also calculated, as these are independent risk factors for coronary artery disease. In the present study, blood pressure measurements and lipid analysis were performed for hypertensive patients (n=200) and normotensive (n=200) controls belonging to Arora sub-group. The blood pressure measurements (mmHg) of all participants were taken using standard methodology as recommended by IGH-III (2013), after the participants had been made comfortable and had rested. Serum levels of total cholesterol (TC), triglycerides (TG) and high-density lipoprotein-cholesterol (HDL‑C) were determined on a semi-automated analyzer using commercial kits containing specific standards (Angstrom, Vadodra, India). The results revealed elevated levels of TC (1.41 times, 260.72 ±3.86 mg/dl), TG (1.7 times, 226.97±4.33mg/dl), LDL-C (1.68 times, 196.80±3.57 mg/dl), VLDL-C (1.7 times,45.39±0.87mg/dl) and decreased levels of HDL-C (1.29 times, 35.54±0.77 mg/dl) in patients in comparison to the respective controls values (184.34 ±2.49 mg/dl, 133.62 ±2.27 mg/dl, 117.36±2.71 mg/dl, 26.72±0.45 mg/dl, 45.89 ±0.69 mg/dl).In patients, TC levels were significantly (p≤0.01) elevated in males whereas TG levels were elevated in females (p≤0.001). LDL-C levels were also elevated but not significantly in females and the reverse was observed for HDL-C. In patients, the TG/HDL-C and LDL-C/HDL-C ratios were significantly (p≤0.001) higher in females while TC/HDL-C ratio was higher in males. In controls, all indices as well as TG and LDL-C levels were higher in females. The elevated lipid and lipoproteins levels in hypertensive patients were indicative of dyslipidemia. In the light of other studies and as observed in the participants of the present study, hypertensive individuals are at higher CVD/CAD risk because of elevated lipid levels.

Speaker
Biography:

Abstract:

Background: High Blood pressure affects more than a quarter of the global adult population. It is projected in year 2025 to increase by 24% in developed countries and 80% in developing countries. The increase is expected to be much higher than these projections. National surveys of prevalence, awareness, treatment, and control provide basis for assessing the burden of hypertension in the community.

Objectives: To determine prevalence of high blood pressure among different population segments of Dubai population and the patterns of distributions.

Methodology: Dubai Household Health Survey was conducted in 2014 as a Cross-sectional, multistage, stratified, Cluster survey. Houses were visited to obtain detailed information on the different health-related issues. According to Dubai Statistical Center, the total population of Dubai at the end of 2014 was 2327350 (males 1613175, females 714175) (UAE 212000, Expatriates 2115350). Individuals aged ≥18 years were investigated for the history hypertension. Related questions of the questionnaire were asked to 3716 persons. Data were entered to the computer using Excel sheet and analyzed using SPSS 21.

Results: The study showed that about 2.5% of males, 2.8 of female, and 2.5% of the total  in the age group 18-59 years are diagnosed as hypertensive. When combined with elderly, 3.2% of males, 5.1% of females and 3.5% of the total are diagnosed as hypertensive. When it comes to nationality, the study showed that about 18.9% of total Emirati have diagnosed as hypertensive, 20.0% of males and 18.0% of females.

Conclusion: Almost one quarter of  Dubai Emirati population have been diagnosed as having high blood pressure. One in each four individuals are hypertensive. This greatly puts them at risk of developing cardiovascular morbidity and mortality at long term. National screening, national registry, awareness, population-based interventions, policies and legislations are needed to be addressed as top priority.

 

Speaker
Biography:

Dedy Arisjulyanto is one of the postgraduate students of Public Health Universitas Gadjah Mada, he has expertise in overcoming non-communicable diseases with complementary therapy, this research was conducted directly in the community and analyzed it by the quantitative way and various theoretical references, this research became a very good recommendation in overcoming hypertension problem in the world.

Abstract:

Purpose: Hypertension is one of the leading causes of mortality in Indonesia, there is a significantly increasing trend in annual hypertension prevalence in Indonesia. Hypertension is one of the most common diseases in NTB, the prevalence of hypertension measured based on blood pressure in NTB is 1,523,574 (32.4%), it is higher than the national rate (1,255,537 (26.7%) of 4,702,389 people). The highest prevalence of hypertension in Mataram City is in Cakranegara Primary Care, there are 724 people with hypertension in this primary care working area. The purpose of this study is to determine the average number of the patient’s hypertension rate at Cakranegara Primary Care before and after given muscle relaxation techniques.

Method: This study uses "Quasi-Experiment Design" with the control group as comparison. The population in this study are 724 hypertension patients and 27 patients as sample based on inclusion and exclusion criteria.

Results: The results of this study indicate that the T-test calculation using Quasi-Experiment Design shows the difference in the average of hypertension rate before and after given progressive muscle relaxation technique. It is 10,306 mmHg in the intervention group and 1,425 mmHg in the control group. The p-value in the intervention group is 0.000 that is smaller than α = 0.05 and the p-value of the control group is 0.431 that is greater than α = 0.05.

Conclusion: From this study, we can conclude that there is a difference in hypertension rate between the intervention and control group. We hope this progressive muscle relaxation technique can be used as an appropriate alternative or complementing treatment to control Hypertension rate.

Speaker
Biography:

Has completed M.Phil in Human Genetics, Centre for human genetics from Hazara University, Pakistan.

Abstract:

Hypertension is the leading cause of many major diseases including coronary heart disease, stroke, renal disease, peripheral vascular disease and other disorders. With the genetic factors there are also many environmental factors that cause hypertension. One of major cause of hypertension is due to mutations in the mitochondrial DNA .In this study a total of 100 hypertensive patients were analysed for detection of mutation A4300G but only 30 patients (30%) were found to have this mutation in their tRNAIle gene which is associated with heart disease i.e Left Ventricular Hypertrophy (LVH) and cause hypertension. In this mutation A4300G, it change the structure of tRNA due to which tRNA capacity of attaching specific nucleotide to mRNA is disturbed and have lethal consequences on patients health. Unfortunately local people are unaware of the fact that hypertension quietly causing the cardiovascular diseases including LVH etc. By this research we can aware local community and doctors especially to proper guide patients about hypertension its long term impacts on the individual and community help

Speaker
Biography:

Abstract:

Background: This review focuses on urban and rural parts of central Thailand, north Thailand, east Thailand, west Thailand, south Thailand and northeast of Thailand. A Literature Review of the prevalence, awareness, control of hypertension and risk factors among Thailand patients. 
Methods: This literature review was guided by the Joanna Briggs Institute of Australia for Systematic Review and Meta-Analysis. The following databases were search from multiple electronic databases and manual searches of journals were written in English and published in journals from 2005 to 2015, databases were queried using keywords for prevalence, awareness, control of blood pressure (BP) or hypertension (≥140 SBP and or ≥90 DBP) and risk factors among Thailand adults (≥18 years). A total of 62 articles were identified, of which 18 articles were found to be relevant for this study. 
Results: Overall there is a prevalence of hypertension in Thailand. Significant differences in hypertension were noted between rural and urban parts of Thailand. Significant differences were also noted in the rural and urban Thailand  for awareness about how to control hypertension. The risk factors associated with hypertension among Thailand patients include age, alcohol, smoking and chewing tobacco, BMI, central obesity, consumption of low vegetables/ fruits, high consumption of dietary fat and salt, and sedentary activity. 
Conclusion: The rural areas had lesser prevalence of hypertension are compared to urban areas. The differences in hypertension is due to  socioeconomic conditions, risk factors and quality of life. The higher prevalence of hypertension in urban areas is leading to a rapid increase in cardiovascular disease risk factors among the urban poor and middle class in Thailand. 

  • Hypertension and Nephrology | Hypertension and Diabetes | Cardiovascular Diseases | Cerebrovascular Diseases
Location: Toronto, Canada
Speaker
Biography:

Segundo Mesa Castillo. As Specialist in Neurology, he worked for 10 years in the Institute of Neurology of Havana, Cuba.  He has worked in Electron Microscopic Studies on Schizophrenia for 32 years. He was awarded with the International Price of the Stanley Foundation Award Program and for the Professional Committee to work as a fellowship position in the Laboratory of the Central Nervous System Studies, National Institute of Neurological Diseases and Stroke under Dr. Joseph Gibbs for a period of 6 months, National Institute of Health, Bethesda, Maryland, Washington D.C. USA, June 5, 1990. At present he is member of the Scientific Board of the Psychiatric Hospital of Havana and give lectures to residents in psychiatry.

Abstract:

There is increasing evidences that favor the prenatal beginning of schizophrenia. These evidences point toward intra-uterine environmental factors that act specifically during the second pregnancy trimester producing a direct damage of the brain of the fetus [1]. The current available technology doesn't allow observing what is happening at cellular level since the human brain is not exposed  to a direct analysis in that stage of the life in subjects at high risk of developing schizophrenia. Methods. In 1977 we began a direct electron microscopic research of the brain of fetuses at high risk from schizophrenic mothers in order to finding differences at cellular level in relation to controls. Results. In these studies we have observed within the nuclei of neurons the presence of complete and incomplete viral particles that reacted in positive form with antibodies to herpes simplex hominis type I [HSV1] virus, and mitochondria alterations [2]. Conclusion. The importance of these findings can have practical applications in the prevention of the illness keeping in mind its direct relation to the aetiology and physiopathology of schizophrenia. A study of the gametes or the amniotic fluid cells in women at risk of having a schizophrenic offspring is considered. Of being observed the same alterations that those observed previously in the cells of the brain of the studied foetuses, it would intend to these women in risk of having a schizophrenia descendant, previous information of the results, the voluntary medical interruption of the pregnancy or an early anti HSV1 viral treatment as preventive measure of the later development of the illness.

Speaker
Biography:

Mr Safir Ullah Khan has expertise in the field of human physiology. After one year training at MPhil level he has develop the project to promote a new hypothesis regarding health. This work totally supported by Higher Education Commission Pakistan to build a new criteria and sense regarding health sciences especially in diabetes, hypertension and related CVD’s and importance of T and Cortisol profile in these complications.

Abstract:

Statement of the Problem: Evidence suggests that stressful experiences cause diabetes, which is often associated with premature mortality. In current years, hypogonadism and testosterone (T) deficiency concepts are developing in which males consider as they are the factors which develop insulin resistance and cause diabetes related cardiovascular disease (CVD’s) events. Based on the above observations, it was our working hypothesis that Psychological stress increases physiological stress in terms of increases in cortisol secretion, which suppress reproductive axis and cause diabetes, hypertension (HTN) and cardiovascular diseases. Methodology & Theoretical Orientation: The personal information like marital status, BMI, lifestyle pattern, education level and socio-economic status of male’s patients and sex-, age-, and BMI-matched control subjects was collected by using a structured questionnaire. Psychological stress in patients and sex-, age-, and BMI-matched healthy subjects were determined by using depression, anxiety and stress scale (DASS). The plasma concentrations of T and cortisol were measured using specific RIA systems. Findings: There was a positive correlation between mean plasma concentrations of cortisol and T in the age groups of 41-50 and 51-60 years of patients. Mean plasma concentrations of cortisol were positively correlated with the mean systolic B.P., mean diastolic B.P. and mean blood glucose random in the age groups of 41-50 and 51-60 years and with mean blood glucose fasting in the age group of 41-50 years of patients. Mean plasma concentrations of T were positively correlated with mean systolic B.P. and mean blood glucose random in the age groups of 41-50 and 51-60 years, with diastolic B.P. in the age group of 41-50 years and with blood glucose fasting in the age group of 51-60 years of patients having high cortisol and low T values. Conclusion & Significance: Normal physiologic levels of T and cortisol are beneficial to the male reproductive and CV system. Patients had low T level either they were treated with RAASi or non-RAASi or with combination treatment of RAASi, non-RAASi or they remain untreated. Further the disease was more pronounced in illiterate, lower middle class, overweight and married patients. Mean plasma concentrations of cortisol, T, mean systolic B.P. mean diastolic B.P. and mean blood glucose random of controls and patients differ significantly in all age groups of 21-30 and 41-60 years.

Speaker
Biography:

Anahita Aboonabi works as a researcher in School of Medical Science with the centre of Heart Foundation Institute at the Griffith University. She completed a Master of Philosophy in Nutritional Sciences at the University of Putra Malaysia (UPM) in 2014, investigated the ameliorating effect of antioxidant on diabetic animal modelling. She started her PhD at the Department of Health Science at Griffith University (2015) to continue her research focusing on the role of antioxidant in cardiovascular system based on the novel cellular pathway which has critical for prevention of heart disease.  

Abstract:

Background: Anthocyanin as a potential antioxidant has shown atheroprotective effect on trombonist formation via the activation of nuclear factor erythroid 2-related factor 2 (Nrf2- ARE) pathway benefit.

Objective: This study aimed to   investigate the antithrombotic effect berry-derived anthocyanin supplements on thrombosis risk factors and platelets surface markers in a population with high risk atherosclerosis. 

Design: A total of 52 participants in two groups of normal healthy and at-risk (age 25-75y) were given 320 mg anthocyanin twice daily for 4 weeks in a blinded randomized controlled trail.

Results: Anthocyanin consumption for four weeks, significantly decreased fasting blood glucose (FBG) concentration 11.51 % in at-risk group. Similarly, it was observed a significant reduction on triglyceride and low-density lipoprotein (LDL) levels with 24.86% and 25.7% respectively in the at-risk group compared with normal control group (p < 0.05). Moreover, anthocyanin supplementation reduced high sensitivity C-reactive protein (hs-CRP) as inflammatory biomarker (18%, p < 0.05) with no change in normal group. The positive correlation also established in the at-risk group between decreased hs-CRP values and the levels of LDL-C and FBG (p < 0.05).  Anthocyanin supplementation decreased ADP-induced platelet activation configuration expressed as P-selectin by 40%, and platelet-monocytes aggregates by 49.3%.

Conclusion: Anthocyanin supplementation improves lipid profile, inflammatory marker, blood glucose concentrations, and platelet hyperactivity. These benefits may be due to the activation of Nrf2-ARE.

Speaker
Biography:

Abstract:

Introduction: The influence of ESR1 gene -397T>C polymorphism on the risk of development of coronary artery disease (CAD) in north Indian population was analysed. We hypothesized that this polymorphism may influence the susceptibility to CAD through variation in ERα expression. To examine this concept, we evaluated ERα mRNA expression in peripheral blood leucocytes of CAD patients.

Methodology: The study included hundred angiographically confirmed CAD patients and hundred age and sex matched control subjects. The ERα polymorphisms were investigated by PCR-RFLP. Quantitative Real Time PCR was carried out for the measurement of ERα mRNA expression.

Results: The frequencies of mutant homozygous (CC) and heterozygous (TC) genotypes of ESR1 -397T>C gene polymorphism significantly higher in CAD patients than control subjects. A significantly increased CAD risk was observed in dominant and codominant inheritance models for this polymorphism. The ESR1 mRNA expression was highest in CAD patients with wild type homozygous TT genotype (2-∆ct =0.28 ). A significant mutant ‘C’ allele, dose dependent, fall  in ESR1 mRNA expression was observed with lowest expression in mutant homozygous CC genotype (2-∆ct=0.09 ), and intermediate level of expression in heterozygous TC genotype (2-∆ct=0.14) subgroups of CAD patients.

Conclusions: In conclusion, this study demonstrates a significantly heightened risk of CAD associated with the inheritance of mutant genotypes of ESR1 -397T>C gene polymorphisms. This is the first report of a lowered ERα expression in conjunction with the presence of mutant ‘C’ allele of ESR1 -397T>C polymorphism with associated increased susceptibility to CAD.    

Rasulova

Toshev B.B. Republican Specialized Scientific and Practical Medical Center Therapy And Medical Rehabilitation, Tashkent, Uzbekistan

Title: Influence of lyzinoprile and losartan on the indicators of the functional state of kidneys in patients with chronic heart failure depending on the degree of dysfunction of kidneys
Speaker
Biography:

Rasulova Z.D. has completed his Ph.D. at the age of 30 years from Tashkent Medical Academy. She is the Senior Researcher of the Republican Specialized Scientific and Practical Center for Therapy and Medical Rehabilitation. He has published more than 30 papers in reputed journals.    

Abstract:

 Purpose. To study the effect of lisinopril and losartan on the functional state of the kidneys of patients with I-III functional class (FC) of chronic heart failure (CHF), depending on the degree of renal dysfunction (RD).

Research methods. A total of 223 patients with ischemic heart disease with I-III FC of CHF were examined, initially and after 6 months of treatment. The first group (I) consisted of 118 patients taking lisinopril as part of standard therapy; the second group (II) - 105 patients taking losartan. Also, all patients were divided into 2 groups depending on the estimated rate of the glomerular filtration (eGFR): 30 < eGFR ≤60 ml/min/1.73 m2 - 67 patients (29 patients in the I group, 38 - in the II group), and eGFR > 60 ml/min/1.73m2 -156 patients (89 patients in group 1, 67 patients in group 2).

Results. The nephroprotective effect of standard therapy with the inclusion of lisinopril or losartan was noted, with a significant decrease in the level of enzymes in the urine, as a sign of dysfunction of the tubular kidney apparatus, a decrease in creatinine, and an increase in GFR. In patients with CHF with a preserved RSKF>60 ml/min/1.73 m2 and moderate DP with eGFR = 59-45 ml/min/1.73 m2, the use of standard lisinopril or losartan showed reliable nephroprotection. In patients with CHF with kidney dysfunction with 30>eGFR<45 ml/min/1.73 m2, a significant improvement in renal dysfunction was observed in the group of patients taking standard therapy - losartan.

Conclusion. The results of our study showed the nephroprotective effect of the standard therapy with the inclusion - lisinopril and losartan, with a significant decrease in the level of enzymes in the urine, as a sign of dysfunction of the tubular kidney apparatus, a decrease in creatinine and an increase in GFR, a more pronounced effect was observed in patients taking losartan. 

Speaker
Biography:

Professor Dr. Punit Gupta is MBBS, MD (Medicine), DM (Nephrology) and PhD. He is the Honorary Nephrologists to the Governor of Chhattisgarh State since 2009. He is Chairman and Members of many important academic and management committees of various Government Medical Institutions in the country and the Pt. Deen Dayal Upadhyay Health Sciences University, Raipur.He has guided over 100 Postgraduate & Technologist student for their thesis & Project in Nephrology & Research and also severed as an examiner for the university examinations.A man of researches and publication, he has presented more than 160 research papers and abstracts on Kidney Diseases in Tribal populations at Renowned National and International Conferences. He was felicitated for being the only research scholar who had presented 29 abstracts in Indian Society of Nephrology conference, Pune and 11 research papers at Asia Pacific congress of Nephrology, 2008 in Malaysia on tribal kidney diseases.His Oral Paper was awarded first prize in ISNCON 2007, New Delhi. He was awarded internationally prestigious APCN Developmental awards in Malaysia  2008 and a Follow Scholarship by International Society of Peritoneal Dialysis in Turkey 2008. His paper was recognized as a best Paper in API 2014, Bhilai. He was awarded Certificate of Excellence awards by the Times of India groups 2016. His work was appreciated with certificate of appreciation by Indian Dietician association 2016. He was felicitated by Agrasen Agrawal Samaj for his excellent work in Tribal Population 2016. He was honoured with excellence award by ‘Z’ TV Chhattisgarh for this distinguish work in kidney disease in rural population of Chhattisgarh in 2017. He has developed a concept of Teledialysis, first of its kind in Asia.He has developed Portable dialysis Machine (MAKE-D) for 60 billion kidney patients in world who require dialysis many times in a week. He has developed an abdominal Pressure Measurement Scale, which is very useful of Continuous Ambulatory Peritoneal Dialysis Patients (type of dialysis). He has developed and economic, efficient and effective walkie talkie system for consultation and directions to the hospital staff and doctors. He has been awarded Dr. B. C. Roy National Award for his research to give Aid or Assistance to Research Project for the year 2016.

Abstract:

Introduction: Gastroenteritis is an important cause of acute Kidney Injury. It was reported that gastroenteritis as a cause of Acute Kidney Injury in 22-44.5% of the cases. The severity of illness was assessed using Glassgow Coma Scale (GCS), Sequential Organ Failure Assessment (SOFA) score;Multiorgan dysfunction scores (MODS). These scales and scores help in assessing prognosis and outcome of the patients in study.

Method: The study was conducted in the Department of Nephrology, Pt. J.N.M. Medical College and Dr. B.R.A.M.Hospital, Raipur. 50 patients of Acute Kidney Injury were included for the purpose of study suffering from Acute Gastroenteritis admitted in Nephrology Unit, Pt.J.N.M.Medical College Raipur from was studied by MODS,SOFA and CGS SCORE in Acute Kidney Injury All patients were subjected to routine investigations.

Results: Acute Gastroenteritis associated AKI includes 87.5% males, 12.5% Females. AKI most commonly seen in people of age group 41-50 (62.5%). 68.75% patients presented with features of AKI in first 3 days. CGS score deranged in 50% patients affected by AGE with AKI. MODS score is deranged in 100% of patients suffering fromAGE with AKI. SOFA score is deranged in 100% of patients suffering fromAGE with AKI. Survival rate among patients suffering from AKI associated with AGE is 81.25% while mortality is 18.75%. 50% had Multiorgan dysfunction and among them the mortality was 25% . Mortality is 100% in patients having CGS score 7-11 & 11-13 & no mortality reported in <7 OR >13 GCS score groups suffering from AGE with AKI. Mortality rate of patients having MOD score 9-16 & 5-8 is 100% & 20% respectively and No mortality reported in 0-4 suffering from AGE with AKI. Mortality rate of patients having SOFA score 9-16 & 5-8 is 100% & 16.67% respectively and No mortality reported in 0-4 suffering from AGE with AKI. 43.75% required No.of dialysis is 2 ,more than 4 times dialysis required in 18.75% mean dialysis requirement is 2.75±1.5. 12.5% patients require ventilatory support. Mean days of hospitalization was 9.9±3.6 days.

Conclusion: AGE with Acute Kidney injury was more common in male as compared to female. AKI most commonly seen in people of age group 41-50. Maximum number of patients presented with features of AKI in first 3 days. MODS score is deranged in all patients suffering from AGE with AKI. SOFA score is deranged in all of patients suffering from AGE with AKI. Multi-organ dysfunction seen in half of the patient suffering from AGE with AKI. Mortality of patient having MOD is 25%. 100% mortality seen with CGS 7-11 and 11-13. Maximum dialysis sessions required was 4. 90% survival for AKI with AGE on hemodialysis

  • High Blood Pressure in Adults | Stress Management in Adults | Clinical Evaluation | Etiology and Risk Management
Location: Toronto, Canada
Speaker
Biography:

Anum Salman has completed her MSc at the age of 24 years from Liaquat National Hospital in neuromusculoskeletal rehabilitation. She is working as a physiotherapist in Memon Medical Institute Hospital and has more than 3 years of clinical experience

Abstract:

Background:  Hypertension is the leading cardiovascular problem worldwide. Hypertension persists in the patient for a long time without any symptom which results in weakening of coronary vessels. Hypertension is a major risk factor for stroke, neuropathy and coronary artery disease. Increase blood pressure and lack of exercise is strongly associated with each other.

Aims and objective: The purpose of this study was to explore the effectiveness of lower limb (cycling) and upper limb exercises (arm stretch trainer) in reducing blood pressure in hypertensive patients.

Method: Case-control study was performed on  80 participants with the age between  40 - 60 years. Participants taken for the study were divided into two groups. Group A with 40 participants was receiving upper limb exercises and the Group B with 40 participants were receiving lower limb exercises. Total 10 sessions of both types of exercises were administered.

Result: A statistically significant difference was found in systolic and diastolic pressure before and after the exercises. Systolic blood pressure was reduced to 133.95±4.187 after lower limb exercise and 171.800±5.616 after upper limb exercise. Whereas, diastolic blood pressure was reduced to 84.500±2.83 by using lower limb cycling exercise and 92.27±3.40 by using upper limb exercise. t-test result shows a p-value less than 0.005 of both systolic and diastolic blood pressure.

Conclusion: Both the exercise have impact in reducing blood pressure but patients who want quick recovery should go for lower limb exercises.

Speaker
Biography:

As a Biochemist doctorate along with post graduate in dietetics and food management have passion in challenging research projects based on nutrigenetics. Worked on many genetic association studies in coronary artery disease and diabetic patients. Many research publication in toxigenomics area too.Working on nanoformulations of statins and drug delivery systems to improve the bioavalabilty.

Abstract:

Genetic polymorphisms in glutathione S-transferase (GSTs) genes may modulate the risk of cardiovascular diseases. The objective of present study was to investigate the potential association between the polymorphisms of GSTM1/T1 and P1 genes and their influence on diverse clinical parameters and oxidative stress biomarkers in coronary artery disease (CAD) patients in Asian Indians. Present study includes 562 angiographically confirmed CAD patients and 564 healthy control subjects from north Indian population. Anthropometric and clinical measurements were done in all the participants. The oxidative stress biomarkers including malondialdehyde (MDA) and total antioxidant capacity (TAC) were also measured. The genotyping of GSTM1/T1 and P1 genes was carried out using multiplex-PCR and PCR-RFLP methods. The CAD patients exhibit significantly high values of waist circumference (WC), waist to hip ratio (WHR), Body fat(%), glucose, triglycerides and low-density lipoprotein (LDL), and reduced HDL levels were observed in CAD patients compared to control subjects (p<0.001). MDA levels were significantly enhanced and TAC was reduced in CAD patients compared to controls (p<0.001). However, no significant difference in BMI and total cholesterol levels was observed in CAD patients and control subjects. The frequencies of the GSTM1 and GSTM1/T1 null genotypes in the CAD patients were significantly higher than the control subjects. In contrast, GSTT1(-) genotype frequencies were significantly lower in CAD patients than the controls. Logistic regression analysis of the data revealed null genotype of GSTM1 and GG genotype of GSTP1 (313A/G) gene were associated with 2-fold enhanced risk of developing CAD whereas GSTT1(-) plays a defensive role against CAD development in north Indians. Upon stratification of data according to the genotypes of GSTM1/T1 and P1 genes, we did not find significant difference amongst the various metabolic traits in CAD patients and controls. Our results suggest that oxidative damage induced by lipid peroxidation with reduced antioxidant capacity and genetic variants in GST genes (GSTM1/T1 and P1) may modify the risk of CAD development in Asian Indian population.

Speaker
Biography:

Bhatti is an Assistant Professor having teaching and research experience of >10 years. Recently he finished his post doc fellowship at Texas Tech University Health Sciences Center, Lubbock TX USA under the scheme of Raman Fellowship funded by University Grants Commission Govt. of India. He identified a link between the type 2 diabetes and development of Alzheimer’s dises using a genetic model of type 2 diabetes, TallyHO. He is actively engaged in investigating the genes associated with the risk of developing type 2 diabetes and coronary artery disease (CAD) in Asian Indians. He has published 25 research papers in reputed international journals and presented his findings in various national and international conferences. He is an expertise in the area of gene based personalized medicine. He has identified various life style related risk factors and susceptibility genes in diabetes, CAD and metabolic syndrome.  

Abstract:

Statement of the Problem: Coronary artery disease (CAD) is a multifactorial syndrome that is deemed to be an outcome of the association between genetic and environmental factors. Vitamin D receptor (VDR) is a probable candidate gene for the development of CAD. The purpose of present study was planned to examine the role of single nucleotide polymorphisms (SNPs) in VDR gene and CAD risk in Asian Indians. Methodology: A total of 410 CAD patients and 414 controls were included. Three SNPs in VDR gene (BsmI, TaqI and FokI) were examined using PCR-RFLP method. In addition, the anthropometric and biochemical characteristics were done in all the subjects. Findings: The CAD patients shows pronounced abdominal adiposity reflected by their significantly higher waist circumference, waist to hip ratio, even at the normal BMI values suggested for Asian Indians. Dyslipidemia, represented by high levels of TC and TG, and reduced HDL was an established risk factor for development of CAD. The genotyping data revealed that BsmI-bb genotype might be associated with 2.2-fold increased risk (OR=2.19; 95% C.I. = 1.48-3.19; p=<0.001) whereas FokI-TT homozygotes had a 3.5 fold increased risk for the development of CAD (OR = 3.53; 95% C.I. = 2.33-5.36; p=<0.001). Furthermore, no significant relationship of TaqI polymorphism with CAD risk was observed (OR; 1.35, 95% C.I.; 0.91-1.99, p = 0.161). Conclusion & Significance: The present study demonstrated a significant association of BsmI and FokI variants of VDR gene with augmented possibility of CAD development in Asian Indian population. The conventional risk factors such as age, abdominal obesity and dyslipidemia were independently linked with the amplified risk of CAD. However, metabolic characteristics are not very affected by VDR gene polymorphisms in Asian Indians.  Finding variations in the susceptibility genes that makes people more susceptible to diseases help us in improved therapeutic strategies.  

Speaker
Biography:

As a Biochemist doctorate along with post graduate in dietetics and food management have passion in challenging research projects based on nutrigenetics. Worked on many genetic association studies in coronary artery disease and diabetic patients. Many research publication in toxigenomics area too.Working on nanoformulations of statins and drug delivery systems to improve the bioavalabilty.

Abstract:

Genetic polymorphisms in glutathione S-transferase (GSTs) genes may modulate the risk of cardiovascular diseases. The objective of present study was to investigate the potential association between the polymorphisms of GSTM1/T1 and P1 genes and their influence on diverse clinical parameters and oxidative stress biomarkers in coronary artery disease (CAD) patients in Asian Indians. Present study includes 562 angiographically confirmed CAD patients and 564 healthy control subjects from north Indian population. Anthropometric and clinical measurements were done in all the participants. The oxidative stress biomarkers including malondialdehyde (MDA) and total antioxidant capacity (TAC) were also measured. The genotyping of GSTM1/T1 and P1 genes was carried out using multiplex-PCR and PCR-RFLP methods. The CAD patients exhibit significantly high values of waist circumference (WC), waist to hip ratio (WHR), Body fat(%), glucose, triglycerides and low-density lipoprotein (LDL), and reduced HDL levels were observed in CAD patients compared to control subjects (p<0.001). MDA levels were significantly enhanced and TAC was reduced in CAD patients compared to controls (p<0.001). However, no significant difference in BMI and total cholesterol levels was observed in CAD patients and control subjects. The frequencies of the GSTM1 and GSTM1/T1 null genotypes in the CAD patients were significantly higher than the control subjects. In contrast, GSTT1(-) genotype frequencies were significantly lower in CAD patients than the controls. Logistic regression analysis of the data revealed null genotype of GSTM1 and GG genotype of GSTP1 (313A/G) gene were associated with 2-fold enhanced risk of developing CAD whereas GSTT1(-) plays a defensive role against CAD development in north Indians. Upon stratification of data according to the genotypes of GSTM1/T1 and P1 genes, we did not find significant difference amongst the various metabolic traits in CAD patients and controls. Our results suggest that oxidative damage induced by lipid peroxidation with reduced antioxidant capacity and genetic variants in GST genes (GSTM1/T1 and P1) may modify the risk of CAD development in Asian Indian population.