3^rd Annual Conference on
Hypertension and Cardiovascular Diseases

Biography:

Dr. Kapila has done Ph.D. in human genetics. After completing Ph.D., she was teaching in Khalsa College Amritsar for the past four years. She has published more than six papers in scientific journals. She has been recently appointed as an Assistant Professor in DAV College Jalandhar, Punjab India. 

Abstract:

Essential hypertension is a heterogeneous disorder with both genetic and environmental causal factors responsible for its etiology including dyslipidemia. Dyslipidemia trigger the activation of sympathetic nervous and renin-angiotensin-aldosterone systems and also imbalance the oxidant-antioxidant status causing impaired vasodilation leading to elevated blood pressure (Muñoz-Durango et al, 2016). Therefore, in the present study, lipid profiling was carried out. The atherogenic index (LDL-C/HDL-C), coronary risk index (TG/HDL-C) and ratio of total cholesterol to high density lipoprotein-cholesterol (TC/HDL-C) were also calculated, as these are independent risk factors for coronary artery disease. In the present study, blood pressure measurements and lipid analysis were performed for hypertensive patients (n=200) and normotensive (n=200) controls belonging to Arora sub-group. The blood pressure measurements (mmHg) of all participants were taken using standard methodology as recommended by IGH-III (2013), after the participants had been made comfortable and had rested. Serum levels of total cholesterol (TC), triglycerides (TG) and high-density lipoprotein-cholesterol (HDL‑C) were determined on a semi-automated analyzer using commercial kits containing specific standards (Angstrom, Vadodra, India). The results revealed elevated levels of TC (1.41 times, 260.72 ±3.86 mg/dl), TG (1.7 times, 226.97±4.33mg/dl), LDL-C (1.68 times, 196.80±3.57 mg/dl), VLDL-C (1.7 times,45.39±0.87mg/dl) and decreased levels of HDL-C (1.29 times, 35.54±0.77 mg/dl) in patients in comparison to the respective controls values (184.34 ±2.49 mg/dl, 133.62 ±2.27 mg/dl, 117.36±2.71 mg/dl, 26.72±0.45 mg/dl, 45.89 ±0.69 mg/dl).In patients, TC levels were significantly (p≤0.01) elevated in males whereas TG levels were elevated in females (p≤0.001). LDL-C levels were also elevated but not significantly in females and the reverse was observed for HDL-C. In patients, the TG/HDL-C and LDL-C/HDL-C ratios were significantly (p≤0.001) higher in females while TC/HDL-C ratio was higher in males. In controls, all indices as well as TG and LDL-C levels were higher in females. The elevated lipid and lipoproteins levels in hypertensive patients were indicative of dyslipidemia. In the light of other studies and as observed in the participants of the present study, hypertensive individuals are at higher CVD/CAD risk because of elevated lipid levels.