Griffith University, Australia
Anahita Aboonabi works as a researcher in School of Medical Science with the centre of Heart Foundation Institute at the Griffith University. She completed a Master of Philosophy in Nutritional Sciences at the University of Putra Malaysia (UPM) in 2014, investigated the ameliorating effect of antioxidant on diabetic animal modelling. She started her PhD at the Department of Health Science at Griffith University (2015) to continue her research focusing on the role of antioxidant in cardiovascular system based on the novel cellular pathway which has critical for prevention of heart disease.
Background: Anthocyanin as a potential antioxidant has shown atheroprotective effect on trombonist formation via the activation of nuclear factor erythroid 2-related factor 2 (Nrf2- ARE) pathway benefit.
Objective: This study aimed to investigate the antithrombotic effect berry-derived anthocyanin supplements on thrombosis risk factors and platelets surface markers in a population with high risk atherosclerosis.
Design: A total of 52 participants in two groups of normal healthy and at-risk (age 25-75y) were given 320 mg anthocyanin twice daily for 4 weeks in a blinded randomized controlled trail.
Results: Anthocyanin consumption for four weeks, significantly decreased fasting blood glucose (FBG) concentration 11.51 % in at-risk group. Similarly, it was observed a significant reduction on triglyceride and low-density lipoprotein (LDL) levels with 24.86% and 25.7% respectively in the at-risk group compared with normal control group (p < 0.05). Moreover, anthocyanin supplementation reduced high sensitivity C-reactive protein (hs-CRP) as inflammatory biomarker (18%, p < 0.05) with no change in normal group. The positive correlation also established in the at-risk group between decreased hs-CRP values and the levels of LDL-C and FBG (p < 0.05). Anthocyanin supplementation decreased ADP-induced platelet activation configuration expressed as P-selectin by 40%, and platelet-monocytes aggregates by 49.3%.
Conclusion: Anthocyanin supplementation improves lipid profile, inflammatory marker, blood glucose concentrations, and platelet hyperactivity. These benefits may be due to the activation of Nrf2-ARE.