Arid University, Pakistan
Title: An investigation in to the circulating cortisol and testosterone in diabetic hypertensive and cardiovascular patients
Mr Safir Ullah Khan has expertise in the field of human physiology. After one year training at MPhil level he has develop the project to promote a new hypothesis regarding health. This work totally supported by Higher Education Commission Pakistan to build a new criteria and sense regarding health sciences especially in diabetes, hypertension and related CVD’s and importance of T and Cortisol profile in these complications.
Statement of the Problem: Evidence suggests that stressful experiences cause diabetes, which is often associated with premature mortality. In current years, hypogonadism and testosterone (T) deficiency concepts are developing in which males consider as they are the factors which develop insulin resistance and cause diabetes related cardiovascular disease (CVD’s) events. Based on the above observations, it was our working hypothesis that Psychological stress increases physiological stress in terms of increases in cortisol secretion, which suppress reproductive axis and cause diabetes, hypertension (HTN) and cardiovascular diseases. Methodology & Theoretical Orientation: The personal information like marital status, BMI, lifestyle pattern, education level and socio-economic status of male’s patients and sex-, age-, and BMI-matched control subjects was collected by using a structured questionnaire. Psychological stress in patients and sex-, age-, and BMI-matched healthy subjects were determined by using depression, anxiety and stress scale (DASS). The plasma concentrations of T and cortisol were measured using specific RIA systems. Findings: There was a positive correlation between mean plasma concentrations of cortisol and T in the age groups of 41-50 and 51-60 years of patients. Mean plasma concentrations of cortisol were positively correlated with the mean systolic B.P., mean diastolic B.P. and mean blood glucose random in the age groups of 41-50 and 51-60 years and with mean blood glucose fasting in the age group of 41-50 years of patients. Mean plasma concentrations of T were positively correlated with mean systolic B.P. and mean blood glucose random in the age groups of 41-50 and 51-60 years, with diastolic B.P. in the age group of 41-50 years and with blood glucose fasting in the age group of 51-60 years of patients having high cortisol and low T values. Conclusion & Significance: Normal physiologic levels of T and cortisol are beneficial to the male reproductive and CV system. Patients had low T level either they were treated with RAASi or non-RAASi or with combination treatment of RAASi, non-RAASi or they remain untreated. Further the disease was more pronounced in illiterate, lower middle class, overweight and married patients. Mean plasma concentrations of cortisol, T, mean systolic B.P. mean diastolic B.P. and mean blood glucose random of controls and patients differ significantly in all age groups of 21-30 and 41-60 years.